Body weight has surprising, alarming impact on brain function: Higher BMI is linked to decreased cerebral blood flow, which is associated with increased risk of Alzheimer’s disease and mental illness – Science Daily – 2020-08-05

As a person’s weight goes up, all regions of the brain go down in activity and blood flow, according to a new brain imaging study in the Journal of Alzheimer’s Disease.

One of the largest studies linking obesity with brain dysfunction, scientists analyzed over 35,000 functional neuroimaging scans using single-photon emission computerized tomography (SPECT) from more than 17,000 individuals to measure blood flow and brain activity. Low cerebral blood flow is the #1 brain imaging predictor that a person will develop Alzheimer’s disease. It is also associated with depression, ADHD, bipolar disorder, schizophrenia, traumatic brain injury, addiction, suicide, and other conditions.

“This study shows that being overweight or obese seriously impacts brain activity and increases the risk for Alzheimer’s disease as well as many other psychiatric and cognitive conditions,” explained Daniel G. Amen, MD, the study’s lead author and founder of Amen Clinics, one of the leading brain-centered mental health clinics in the United States.

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